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In this issue...

Innovation – the centre of corporate strategiese
Lord Sainsbury, UK Minister for Science and Innovation
British Innovations
On the road again
Christopher Macgowan, Chief Executive, Society of Motor Manufacturers and Traders
Fossil Fuels – An Energy source for the Future
Greg Lewin, President, Shell Global Solutions
Chain of success
Kenny McKay, Director, and Will Wright, Manager, Restructuring practice at KPMG
Innovation and the Patent Office
Lawrence Smith-Higgins, Head of Awareness Information & Media The UK Patent Office
Benefits of association
Dr Michael Moore, CEO, PIramed Ltd
Innovation and strength in the UK biotech sector
Aisling Burnand, Chief Executive, BioIndustry Association
Simfonec: Helping make good research BIG business
Heron Evidence Development: Successful deal of missed opportunity
Springwell Ltd: Match-maker for Innovative Technologies
Korn/Ferry International: Pharmaceutical companies desire to break the mould
A quality core interface
Dominique Kleyn head of BioPharma Business Development, Imperial College London
Evolutec Group: Creating a range of commercial options
Moving forward
Dr Ceri Williams, Senior Manager, Science and Innovation at Yorkshire Forward and Dr Danielle Hankin, Bioscience Cluster Manager
Oxitech: Revolutionising SIT Programmes
Oxford Expression Technologies: Meeting the needs of the post-genomic era
Business Services
Innovating business related services
Norma Rose, Director-General, Business Services Association
BT: Innovation Strategy and Innovation Continuum
UK Film Council: How the UK wins in the international film industry?
On the defence
Major General Alan Sharman CBE, Director General, Defence Manufacturers Association
ProEtch: Precision parts of quality
Wallop Defence Systems: Aircraft Countermeasures and the Dual Spectral Threat
Education, Education, Education
Ruth Kelly, Secretary of State for Education and Skills
Applied Sciences at Wolverhampton - Innovation in Higher Education Professor Trevor Hocking, Associate Dean, International Development
Wind energy
Marus Rand, Chief Executive, British Wind Energy Association
Vital energy
Ian Leitch, Commercial Director, Energy Industries Council
Waterman Group: Solutions to solve climate control legislation
Winning the war against germs
Dr Ron Mitchell, Managing Director, GB Environmental
Show me the money! Funding for innovation – who can help?
UK: Innovation Nation?
Launching the “Innovation Nation?” initiative
Innovation in the 21st Century
Gemma Harman, Director of Strategy & Media, BT Chief Technology Office
UK Manufacturing - a driving force for innovation
Andrew Manly, Director General, Manufacturing Technologies Association
Waterman Group: Single project model 3D
Renishaw: Achieving global manufacturing competitiveness in the UK
Yorkshire Forward
The European Nanotechnology Trade Alliance
Del Stark, Chief Executive, European Nanotechnology Trade Alliance
University research drives a new wave of innovation
Omar Cheema, Nanotechnology Business Development, Imperial College London
Oxford Instruments: Enabling nanoscience and nanotechnology
Semefab (Scotland): A real driver of change
Metal Nanopowders: New products that meet your needs
Regional Development
London Development Agency: One jump ahead
91Advantage West Midlands: At the heart of it all 95


Oxford Expression Technologies - "meeting the needs of the post-genomic eraâ€

Oxford Expression Technologies (OET), a commercial unit operating from the Insect Virus Research Group at Oxford Brookes University launched its first product, FlashBAC? in April 2004

Simultaneous virus production in 96-well plates

OET was started by Linda King, Dean of Biological Sciences and Professor of Insect Virology at Oxford Brookes University and Robert Possee, Professor of Virology at the Natural Environment Research Council Centre for Ecology and Hydrology, Oxford. Professors King and Possee have collaborated over many years and have developed world-renowned expertise in the genetics and molecular biology of insect viruses and their applications in the fields of biotechnology and agriculture.

The group is now in a position to be able to exploit the jointly developed patented research in this exciting new platform technology. FlashBAC? is a one-step baculovirus expression technology designed specifically for high throughput and automated use which enables academics, biotech companies and pharmaceutical companies to be able to explore the function of proteins more quickly and efficiently. Following the sequencing of the human genome, the quest is now on to turn the knowledge of our genetic make-up into research breakthroughs that could lead to new drugs and treatments for disease. The sequencing of the human genome provided a list of the thousands of genes in the human body. Although this was a great achievement, it was just the start.

All genes produce different proteins, and it is these that offer the most exciting possibilities. By investigating the effects of individual proteins within the body, we can target specific proteins for further research and potential drug design. But how do we find out what all these proteins do, and whether any of them offer a potential therapeutic benefit? To answer this question there need to be technologies capable of producing the vast number of different proteins for research from the library of genes that has come from the Human Genome Project.

There are currently three main methods of achieving this:

Fully automated recombinant baculovirus production

FlashBAC? allows researchers to produce protein from genes using the baculovirus system many times faster than has previously been possible. The old technology is limited in its use as it needs skilled technicians at several stages and is therefore very costly and time-consuming.

FlashBAC? revolutionises this. The new technology not only reduces the time and effort needed to produce a recombinant baculovirus (the vehicle required to produce the chosen protein), but also for the first time allows simultaneous production of many viruses, each expressing a different gene and so producing a different protein, so potentially enabling thousands of proteins to be produced simultaneously and quickly. Importantly, this technique now requires so few manipulations that the process can be automated. Therefore with the use of robotics equipment, it is now possible to produce highquality proteins on an industrial scale.

Professor Linda King, Dean of BMS and co-inventor of the new technology, said: ?FlashBAC? is a real breakthrough in protein production. We are pleased to be able to offer the technology to scientists worldwide to further their research into protein function. The end results are likely to be of significant benefit in furthering our scientific knowledge?. Oxford Brookes University has also signed an agreement with Cambridge based company NextGen Sciences Ltd., a developer of automated integrated systems for the molecular biology and protein research market, to license FlashBAC? for sale on their robotic platforms.

Insect Virus Research Group at Oxford Brookes University

Dr. Grant Cameron from NextGen said: ?We are delighted to be able to offer this break-through technology with our integrated systems. The combination of our track record of successfully launching new technologies and Professors King and Possee?s world-leading expertise in the field should greatly speed up the worldwide drug discovery process?. The technology is available under a research or commercial licence in kit form directly from OET.

Further details, including information on their custom expression services, troubleshooting and training courses can be found on their website:

OET are also looking for further distributors.